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Bile acid


DATA No : BBA0057 INFORMANT : Takashi Iida

NAME : 1a,3a,7a-Trihydroxy-5b-cholan-24-oic Acid

COMMON NAME: Vulpecholic Acid
SYMBOL:
FORMULA: C24H40O5 MOL.WT (average) : 408.571


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:150-152degC(Ref. 0039)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:Me ester 1H-NMR (CDCl3; 90MHz) d: 0.76 (3H, s, 18-CH3), 0.90 (3H, bd, 21-CH3), 1.11 (3H, s, 19-CH3), 2.5-3.5 (br), 3.30 (bd), 3.68 (S, COOMe), 3.85 (bs)(Ref. 0039)
Me ester 13C-NMR (CDCl3; 22.53MHz) d: C-1 79.21, C-2 40.08, C-3 67.99, C-4 39.20, C-5 39.20, C-6 34.15, C-7 69.08, C-8 40.57, C-9 34.69, C-10 39.65, C-11 23.10, C-12 40.08, C-13 42.25, C-14 50.22, C-15 24.00, C-16 27.90, C-17 56.20, C-18 11.74, C-19 18.73, C-20 35.37, C-21 18.29, C-22 22.98, C-23 30.98, C-24 174.88, C-25 51.52(Ref. 0039)

MASS SPECTRA:(15eV) m/z: 408 (M+, 6%), 390(M-18, 99%), 372(M-2H2O, 100%), 368(M-2H2O-4H, 40%), 357(M-2H2O-CH3, 14%), 354 (M-3H2O, 15%), 302(RDA-ion, 36%), 300 (10%), 289 (M-H2O-SC, 11%), 280(M-SC-C-16,17, 10%), 244(M-2H2O-SC-C-16,17, 10%)(Ref. 0039)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
Isolated from the gallbladaer bile of the Australian opossum, Trichosurus vulpecula (Lesson).(Ref. 0039)
Primary bile acid in Australian marsupials.(Ref. 0102)
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0039]
AUTHOR:Lee, S. P., Lester, R., and Pyrek, J. S.
TITLE:Vulpecholic acid (1 alpha, 3 alpha, 7 alpha-trihydroxy-5 beta-cholan-24-oic acid): a novel bile acid of a marsupial, Trichosurus vulpecula (Lesson) PubMed ID:3559398
JOURNAL:J Lipid Res.
VOL:28 PAGE : 19-31 (1987)
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[0102]
AUTHOR:Hofmann, A. F., Schteingart, C. D., and Hagey, L. R. (1995) Species Differences in Bile Acid Metabolism, in Bile Acids in Liver Diseases (Paumgartner, G., and Beuers, U. eds), pp 3-30, Kluwer Academic Publishers, Dordrecht.
TITLE:
JOURNAL:
VOL: PAGE : - ()
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.