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Bile acid


DATA No : BBA0108 INFORMANT : Takashi Iida

NAME : 3a,11a,15b-Trihydroxy-5b-cholan-24-oic Acid

COMMON NAME:
SYMBOL:
FORMULA: C24H40O5 MOL.WT (average) : 408.571


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:153-155degC(Ref. 0056)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:Me ester: nmax cm-1: 3408, 3380, 2934, 2863, 1723(Ref. 0056)

NMR SPECTRA:1H-NMR (CD3OD; 300MHz) d: 18-Me 0.95(s), 21-Me 0.98(d), 19-Me 1.08(s), 3b-H 3.57(m), 11b-H 3.79(td, J, 10.7, 4.2), 15a-H 4.14(td, J, 5.6, 0.9)(Ref. 0056)
Me ester 13C-NMR (25MHz) d: C-1 39.2, C-2 33.0, C-3 71.7, C-4 38.2, C-5 44.5, C-6 28.4, C-7 25.9, C-8 31.5, C-9 47.9, C-10 -, C11 68.6, C-12 54.0, C-13 -, C-14 60.7, C-15 69.0, C-16 42.4, C-17 56.9, C-18 16.4, C-19 24.4, C-20 35.9, C-21 18.8, C-22 31.5, C-23 31.5, C-24 - (Ref. 0056)

MASS SPECTRA:Molecular secondary ion mass spectrometry m/z: 431(M+Na)+, 415(M+Li)+(Ref. 0056)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
A microbiological transformation product of litocholic acid by a fungus Cunninghamella blakesleeana ST-22.(Ref. 0056)
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0056]
AUTHOR:Jodoi, Y., Nihira, T., Naoki, H., Yamada, Y., and Taguchi, H.
TITLE:New Trihydroxy Bile Acids Produced by Cunninghamella blakesleeana ST-22 from Lithocholic Acid.
JOURNAL:Tetrahedron.
VOL:43 PAGE : 487 -492 (1987)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.