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Bile acid


DATA No : BBA0111 INFORMANT : Takashi Iida

NAME : 3a,12a,16a-Trihydroxy-5b-cholan-24-oic Acid

COMMON NAME: Pythocholic Acid
SYMBOL:
FORMULA: C24H40O5 MOL.WT (average) : 408.571


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:186-187degC, (Me ester: mp, 146-148degC)(Ref. 0059)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:[a]d-23: +28pm1deg (C=1.2, CHCl3) (Me ester)(Ref. 0059)

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:Me ester-3,7,16-triacetate 1H-NMR(CDCl3; 360MHz) d: 18-Me 0.781(s), 21-Me 0.8.37(d), 19-Me 0.909(s), -OCOMe 2.032(s), 2.048(s), 2.169(s) and 3.650(s), 3b-H 4.701(m), 16b-H 4.908(bt, J, 7.2), 12b-H 5.035(bs)(Ref. 0102/0103)

MASS SPECTRA:The spectrum (70eV) was shown as the Me-TMS derivative(Ref. 0007)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
Constituent of bile acid of boa and python.(Ref. 0059)
Isolated from certain primitive snakes, boas and pythons.(Ref. 0100)
Bile acid identified in snake.(Ref. 0102)
A main constituent of the bile of African python.(Ref. 0238)
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0007]
AUTHOR:Lawson, A. M., and Setchell, K. D. R. (1988) Mass Spectrometry of Bile Acids, in The Bile Acids-Chemistry, Physiology, and Metabolism (Vol. 4: Methods and Applications) (Setchall, K. D. R., Kritchevsky, D., and Nair, P. P. eds), pp 167-267, Plenum Press, New York.
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[0059]
AUTHOR:Haslewood, G. A., and Wootton, V. M.
TITLE:Comparative studies of 'bile salts'. 2. Pythocholic acid PubMed ID:14848030
JOURNAL:J Biochem (Tokyo).
VOL:49 PAGE : 67-71 (1951)
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[0100]
AUTHOR:Haselwood, G. A. D. (1978) The Biological Importance of Bile Salts, in Frontiers of Biology (Vol. 47) (Neuberger, A., and Tatum, E. L. eds), North-Holland Publishing Co., Amsterdam.
TITLE:
JOURNAL:
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[0102]
AUTHOR:Hofmann, A. F., Schteingart, C. D., and Hagey, L. R. (1995) Species Differences in Bile Acid Metabolism, in Bile Acids in Liver Diseases (Paumgartner, G., and Beuers, U. eds), pp 3-30, Kluwer Academic Publishers, Dordrecht.
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[0103]
AUTHOR:Hagey, L. R., Schteingart, C. D., and Hofmann, A. F. (1995) New, Natural Bile Acids: Implications for Bile Acid Evolution, in Bile Acids in Gastroenterology Basic and Clinical Advances (Hofmann, A. F., Paumgartner, G., and Stiehl, A. eds), pp 3-7, Kluwer Academic Publishers, Dordrecht.
TITLE:(Hagey, L. R. (1992), Ph. D. Thesis, Bile Acid Biodiversity in Vertebrates: Chemistry and Evolationury Implications, Universty of California. San Diego)
JOURNAL:
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[0238]
AUTHOR:Haslewood, G. A. D., and Wootton, V.
TITLE:Comparative Studies of `Bile Salts'.
JOURNAL:Biochem. J.
VOL:47 PAGE : 584 -597 (1950)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.