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Bile acid


DATA No : BBA0246 INFORMANT : Takashi Iida

NAME : 1b,3a,7b-Trihydroxy-5b-cholan-24-oic Acid

COMMON NAME:
SYMBOL:
FORMULA: C24H40O5 MOL.WT (average) : 408.571


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA:Me-TMS ether m/z: 623, 549, 548, 459, 458, 396, 368, 218, 217, 195, 143(Ref. 0124)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
Identified in urine of a patient with cerebrotendinous xanthomatosis, during oral administration of ursodeoxycholic acid.(Ref. 0124)
Identified in serum, faeces, liver tissue and urine from patients with primary biliary cirrhosis.(Ref. 0149/0176/0200)
Identified in serum and urine of patients with intrahepatic cholestasis of pregnancy.(Ref. 0188)
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0124]
AUTHOR:Koopman, B. J., Wolthers, B. G., van der Molen, J. C., Nagel, G. T., and Kruizinga, W.
TITLE:Abnormal urinary bile acids in a patient suffering from cerebrotendinous xanthomatosis during oral administration of ursodeoxycholic acid PubMed ID:3801500
JOURNAL:Biochim Biophys Acta.
VOL:917 PAGE : 238-246 (1987)
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[0149]
AUTHOR:Batta, A. K., Arora, R., Salen, G., Tint, G. S., Eskreis, D., and Katz, S.
TITLE:Characterization of serum and urinary bile acids in patients with primary biliary cirrhosis by gas-liquid chromatography-mass spectrometry: effect of ursodeoxycholic acid treatment PubMed ID:2621422
JOURNAL:J Lipid Res.
VOL:30 PAGE : 1953-1962 (1989)
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[0176]
AUTHOR:Jonsson, G., Hedenborg, G., Wisen, O., and Norman, A.
TITLE:Presence of bile acid metabolites in serum, urine, and faeces in cirrhosis PubMed ID:1411266
JOURNAL:Scand J Clin Lab Invest.
VOL:52 PAGE : 555-564 (1992)
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[0188]
AUTHOR:Meng, L. J., Reyes, H., Palma, J., Hernandez, I., Ribalta, J., and Sjovall, J.
TITLE:Effects of ursodeoxycholic acid on conjugated bile acids and progesterone metabolites in serum and urine of patients with intrahepatic cholestasis of pregnancy PubMed ID:9453429
JOURNAL:J Hepatol.
VOL:27 PAGE : 1029-1040 (1997)
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[0200]
AUTHOR:Shoda, J., Osuga, T., Mahara, R., Tohma, M., Matsuura, K., Tanaka, N., Matsuzaki, Y., and Miyazaki, H.
TITLE:Altered metabolism of bile acids in cholestasis: determination of 1 beta- and 6 alpha-hydroxylated metabolites PubMed ID:2745625
JOURNAL:J Chromatogr.
VOL:488 PAGE : 315-328 (1989)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.