Back to HOME

Bile acid


DATA No : BBA0249 INFORMANT : Takashi Iida

NAME : 3a,7b,22x-Trihydroxy-5b-cholan-24-oic Acid

COMMON NAME:
SYMBOL:
FORMULA: C24H40O5 MOL.WT (average) : 408.571


Download ChemDraw structure data
BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA:Me-TMS ether m/z: 623(M-15), 548(M-TMSOH), 458(M-2TMSOH), 443(M-15-2TMSOH), 368(M-3TMSOH), 353(M-15-3TMSOH), 464(M-175), 374(M-175-TMSOH), 284(M-175-2TMSOH), 175(C-22+C-23+C24)(Ref. 0124)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
Identified in urine of a patient with cerebrotendinous xanthomatosis, during oral administration of ursodeoxycholic acid.(Ref. 0124)
Identified in serum and urine of patients with intrahepatic cholestasis of pregnancy.(Ref. 0188)
CHEMICAL SYNTHESIS
Stereochemistry of a hydroxyl group at C-22 is unidentified(Ref. 0124)
METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0124]
AUTHOR:Koopman, B. J., Wolthers, B. G., van der Molen, J. C., Nagel, G. T., and Kruizinga, W.
TITLE:Abnormal urinary bile acids in a patient suffering from cerebrotendinous xanthomatosis during oral administration of ursodeoxycholic acid PubMed ID:3801500
JOURNAL:Biochim Biophys Acta.
VOL:917 PAGE : 238-246 (1987)
[TOP]

[0188]
AUTHOR:Meng, L. J., Reyes, H., Palma, J., Hernandez, I., Ribalta, J., and Sjovall, J.
TITLE:Effects of ursodeoxycholic acid on conjugated bile acids and progesterone metabolites in serum and urine of patients with intrahepatic cholestasis of pregnancy PubMed ID:9453429
JOURNAL:J Hepatol.
VOL:27 PAGE : 1029-1040 (1997)
[TOP]

Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.