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Bile acid


DATA No : BBA0257 INFORMANT : Takashi Iida

NAME : 3a,12a,19-Trihydroxy-5b-cholan-24-oic Acid

COMMON NAME:
SYMBOL:
FORMULA: C24H40O5 MOL.WT (average) : 408.571


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:138-140degC(Ref. 0128)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:[a]d-23: +58.5deg (C=1.36, MeOH)(Ref. 0128)

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:nmaxcm-1: 3350, 2650, 1690(Ref. 0128)

NMR SPECTRA:1H-NMR (Pyridine-d5; 400MHz) d: 18-Me 0.73(s), 19-H2 3.57 and 3.82(d, J=10Hz), 21-Me 1.16(d, J=6Hz), 3b-H 3.90(m), 12b-H 4.16(brs)(Ref. 0128)

MASS SPECTRA:Me-DMES ether (70eV) m/z: 459(M-DMESOH-117), 355(M-2DMESOH-117), 472(M-2DMESOH), 369(M-2DMESOH-DMESO), 253(M-3DMESOH-SC)(Ref. 0128)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0128]
AUTHOR:Kurosawa, T., Nomura, Y., Mahara, R., Yoshimura, T., Kimura, A., Ikegawa, S., and Tohma, M.
TITLE:Synthesis of 19-hydroxylated bile acids and identification of 3 alpha,7 alpha,12 alpha,19-tetrahydroxy-5 beta-cholan-24-oic acid in human neonatal urine PubMed ID:7586081
JOURNAL:Chem Pharm Bull (Tokyo).
VOL:43 PAGE : 1551-1557 (1995)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.