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Bile acid


DATA No : BBA0285 INFORMANT : Takashi Iida

NAME : (23S)-3a,12a,23-Trihydroxy-5b-cholan-24-oic Acid

COMMON NAME:
SYMBOL:
FORMULA: C24H40O5 MOL.WT (average) : 408.571


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:225degC, (Me ester; mp, 143-144degC)(Ref. 0053)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:[a]d-20: +38deg (C=1.8, EtOH), [a]d-20: +56.7deg (C=1.8, EtOH) (Me ester)(Ref. 0053)

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:Me ester: nmaxcm-1: 1730 (C=O), 3500 (OH)(Ref. 0053)

NMR SPECTRA:Me ester 1H-NMR (CDCl3+CD3OD) d: 18-Me 0.69(s), 19-Me 0.91(s), 21-Me 1.07(d), 3b-H and 3timesOH 3.17(m), COOMe 3.97(s), 12b-H 4.01(m), 23-H 4.26(m)(Ref. 0053)
Me ester 13C-NMR d: C20 34.39, C21 18.26, C22 41.29, C23 70.14, C24 172.20, C25 52.15(Ref. 0053)

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[0053]
AUTHOR:Pellicciari, R., Natalini, B., Roda, A., Machado, M. I. L., and Marinozzi, M.
TITLE:Preparation and Physicochemical Properties of Natural (23R)-3a,7a,23- and (23R)-3a,12a,23- Trihydroxylated Bile Acids and Their (23S)- Epimers.
JOURNAL:J. Chem. Soc. Perkin. Trans. I.
VOL: PAGE : 1289 -1296 (1989)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.