Back to HOME

Fatty acid


DATA No : DFA8102 INFORMANT : Tetsuyuki Kobayashi

NAME : 5S,6R-dihydroxy-7E,9E,11Z,14Z-eicosatetraenoic acid

COMMON NAME:
SYMBOL: 5(S),6(R)-DiHETE
FORMULA: C20H32O4 MOL.WT (average) : 336.466


Download ChemDraw structure data
Download Mol format file
BIOLOGICAL ACTIVITY
5(S),6(R)-DiHETE is a weak LTD 4 receptor agonist in guinea pig lung membranes(Ref. 8129). It induces guinea pig ileum contraction with an ED value of 1.3 mM.
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:Soluble in ethanol.
SPECTRAL DATA
UV SPECTRA:lmax:273nm e:40,000

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
5S,6R-DiHETE is a dihydroxy polyunsaturated fatty acid and a nonenzymatic hydrolysis product of leukotriene A 4 .
CHEMICAL SYNTHESIS

METABOLISM
Mouse liver cytosolic epoxide hydrolase catalyzes the conversion of LTA to 5,6-DiHETE(Ref. 8128).
GENETIC INFORMATION

NOTE

REFERENCES
[8128]
AUTHOR:Haeggstrom, J., Wetterholm, A., Hamberg, M., Meijer, J., Zipkin, R., and Radmark, O.
TITLE:Enzymatic formation of 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid: kinetics of the reaction and stereochemistry of the product PubMed ID:2829972
JOURNAL:Biochim Biophys Acta.
VOL:958 PAGE : 469-476 (1988)
[TOP]

[8129]
AUTHOR:Muller, A., Rechencq, E., Kugel, C., Lellouche, J. P., Beaucourt, J. P., Niel, G., Girard, J. P., Rossi, J. C., and Bonne, C.
TITLE:Comparative biological activities of the four synthetic (5,6)-dihete isomers PubMed ID:2633210
JOURNAL:Prostaglandins.
VOL:38 PAGE : 635-644 (1989)
[TOP]

Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.