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Fatty acid


DATA No : DFA8106 INFORMANT : Tetsuyuki Kobayashi

NAME : (pm)5, 6-dihydroxy-8Z,11Z,14Z-eicosatrienoic acid

COMMON NAME:
SYMBOL: (pm)5,6-DiHETrE
FORMULA: C20H34O4 MOL.WT (average) : 338.482


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
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CHEMICAL SYNTHESIS

METABOLISM
Epoxide hydrolases convert the EpETrEs into vicinal diols(Ref. 8130), with the concurrent loss of much of their biological activity. (pm)5,6-DiHETrE is a substrate for sheep seminal vesicle cyclooxygenase, producing 5,6-dihydroxy PGE1 and F1 metabolites in vitro(Ref. 8134).
GENETIC INFORMATION

NOTE

REFERENCES
[8130]
AUTHOR:Oliw, E.H., Guengerich, F.P., and Oates, J.A.
TITLE:Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. PubMed ID:6801052
JOURNAL:J. Biol. Chem.
VOL:257 PAGE : 3771 -3781 (1982)
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[8134]
AUTHOR:Oliw, E. H.
TITLE:Biosynthesis of 5,6-dihydroxyprostaglandin E1 and F1 alpha from 5,6-dihydroxyeicosatrienoic acid by ram seminal vesicles PubMed ID:6548162
JOURNAL:Biochim Biophys Acta.
VOL:795 PAGE : 384-391 (1984)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.