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Fatty acid


DATA No : DFA8107 INFORMANT : Tetsuyuki Kobayashi

NAME : (pm)8,9-dihydroxy-5Z,11Z,14Z-eicosatrienoic acid

COMMON NAME:
SYMBOL: (pm)8,9-DiHETrE
FORMULA: C20H34O4 MOL.WT (average) : 338.482


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BIOLOGICAL ACTIVITY
Epoxide hydrolases convert the EpETrEs into vicinal diols(Ref. 8130), with the concurrent loss of much of their biological activity. The 8(S),9(R)-EpETrE isomer is metabolized by platelet cyclooxygenase to form 8(S),9(R)-THETA, a trihydroxy fatty acid which may act as a renal vasoconstrictor(Ref. 8135).
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REFERENCES
[8130]
AUTHOR:Oliw, E.H., Guengerich, F.P., and Oates, J.A.
TITLE:Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediates. PubMed ID:6801052
JOURNAL:J. Biol. Chem.
VOL:257 PAGE : 3771 -3781 (1982)
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[8135]
AUTHOR:Zhang, J. Y., Prakash, C., Yamashita, K., and Blair, I. A.
TITLE:Regiospecific and enantioselective metabolism of 8,9-epoxyeicosatrienoic acid by cyclooxygenase PubMed ID:1543485
JOURNAL:Biochem Biophys Res Commun.
VOL:183 PAGE : 138-143 (1992)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.