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Fatty acid


DATA No : DFA8137 INFORMANT : Tetsuyuki Kobayashi

NAME : 8R-hydroxy-4Z,6E,10Z-hexadecatrienoic acid

COMMON NAME:
SYMBOL: 8(R)-HHxTrE/2,3,4,5-tetranor 12(R)-HETE
FORMULA: C16H26O3 MOL.WT (average) : 266.376


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
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SPECTRAL DATA
UV SPECTRA:lmax: 234nm e: 23,000

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CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS

METABOLISM
Metabolism of 12(R)-HETE in corneal tissue produces predominantly the compound resulting from the loss of four carbon atoms through b-oxidation from C-1 (Ref. 8169). This metabolite is 8(R)-hydroxy hexadecatrienoic acid (8(R)-HHxTrE) or 2,3,4,5-tetranor 12(R)-HETE.
GENETIC INFORMATION

NOTE

REFERENCES
[8169]
AUTHOR:Nishimura, M., Schwartzman, M. L., Falck, J. R., Lumin, S., Zirrolli, J. A., and Murphy, R. C.
TITLE:Metabolism of 12(R)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(R)-HETE) in corneal tissues: formation of novel metabolites PubMed ID:1929401
JOURNAL:Arch Biochem Biophys.
VOL:290 PAGE : 326-335 (1991)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.