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Fatty acid


DATA No : DFA8139 INFORMANT : Tetsuyuki Kobayashi

NAME : 15R-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid

COMMON NAME:
SYMBOL: 15(R)-HETE
FORMULA: C20H32O3 MOL.WT (average) : 320.466


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
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SPECTRAL DATA
UV SPECTRA:lmax: 236nm e: 27,000

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CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS

METABOLISM
(pm)15-HETE, an autoxidation product of arachidonic acid, is comprised of an equal mixture of 15(R)- and 15(S)-HETE. Aspirin-inactivated human recombinant and ovine COX-2 metabolizes arachidonic acid to 15(R)-HETE (Ref. 8173/8174).
GENETIC INFORMATION

NOTE

REFERENCES
[8173]
AUTHOR:Lecomte, M., Laneuville, O., Ji, C., DeWitt, D. L., and Smith, W. L.
TITLE:Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin PubMed ID:8175750
JOURNAL:J Biol Chem.
VOL:269 PAGE : 13207-13215 (1994)
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[8174]
AUTHOR:Capdevila, J. H., Morrow, J. D., Belosludtsev, Y. Y., Beauchamp, D. R., DuBois, R. N., and Falck, J. R.
TITLE:The catalytic outcomes of the constitutive and the mitogen inducible isoforms of prostaglandin H2 synthase are markedly affected by glutathione and glutathione peroxidase(s) PubMed ID:7880828
JOURNAL:Biochemistry.
VOL:34 PAGE : 3325-3337 (1995)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.