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Steroid


DATA No : SST0086 INFORMANT : Hideaki Nishino

NAME : 17b-Hydroxy-17-methylandrosta-1,4-dien-3-one / 17a-Methyl-17b-hydroxyandrosta-1,4-dien-3-one / 1-Dehydro-17a-methyltestosterone

COMMON NAME: Methandrostenolone
SYMBOL:
FORMULA: C20H28O2 MOL.WT (average) : 300.435


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BIOLOGICAL ACTIVITY
Preparation by microorganism hydrogenation of 17a-methylteststerone. (Ref. 0448) Preparation by reduction of 17a-methylteststerone with SeO2. (Ref. 0449)
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:163-164degC (acetone+ether). (Ref. 0448)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:[a]26/D=0deg (c=1.150 in chloroform). (Ref. 0448)

DENSITY:

SOLUBILITY:Sol in chloroform. (Ref. 0448)
SPECTRAL DATA
UV SPECTRA:UVmax: 245nm (e=15,600). (Ref. 0448)

IR SPECTRA:In methylenechloride: 2.74m, 5.98m, 6.14m, 6.21m, 7.29m, 7.52m, 8.86m, 9.23m, 10.68m, 10.83m, 11.28m, 12.23m. (Ref. 0448)

NMR SPECTRA:

MASS SPECTRA:M/D+356 (dioxan). (Ref. 0448)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS

METABOLISM
Anabolic action (androgen activity). (Ref. 0448)
GENETIC INFORMATION

NOTE

REFERENCES
[0448]
AUTHOR:Vischer,E.,Meystre,Ch.,and Wettstein,A.
TITLE:Herstellung weiterer 1-Dehydro-steroide auf mikrobiologischem Wege. Mikrobiologische Reaktionen, 7. Mitteilung.
JOURNAL:Helv. Chim. Acta
VOL:38 PAGE : 1502 -1507 (1955)
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[0449]
AUTHOR:Meystre,Ch,.Frey,H.,Voser,W.,and Wettstein,A.
TITLE:Gewinnung von 1;4-Bisdehydro-3-oxo-steroiden. Über Steroide, 139. Mitteilung.
JOURNAL:Helv. Chim. Acta
VOL:39 PAGE : 734 -742 (1956)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.