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COMMON NAME | : | Tretinoin/All-Trans Retinoic Acid |
SYMBOL | : | ATRA |
FORMULA | : | C20H28O2 MOL.WT (average) : 300.435 |
BIOLOGICAL ACTIVITY |
PHYSICAL AND CHEMICAL PROPERTIES |
MELTING POINT | : | 179-180![]() |
BOILING POINT | : | |
REFRACTIVE INDEX | : | |
OPTICAL ROTATION | : | |
DENSITY | : | |
SOLUBILITY | : | ether 1.56 acetone 1.09 ethanol 0.33 water 0.01 (W/V%) |
SPECTRAL DATA |
UV SPECTRA | : | lmax=350nm (E1%1cm 1,510 in Ethanol)(Ref. 0013) |
IR SPECTRA | : | 1685,1601,1570,1251,1184,962cm-1(Ref. 0018) |
NMR SPECTRA | : | 1H-NMR(d,CDCl3,220MHz):1.02(6H,1-Me),~1.47(2H,2-CH2),~1.62(2H,3-CH2),1.72(3H,5-Me),2.01(3H,9-Me),~2.02(2H,CH2),2.37(3H,13-Me),5.79(1H,14-H),6.14(1H,J=16.0Hz,8-H),6.15(1H,J=11.5Hz,10-H),6.29(1H,J=16.0Hz,7-H),6.31(1H,J=15.0Hz,12-H), 7.03 (1H,J=11.5,15.0Hz,11-H)(Ref. 0003) 13C-NMR(d,CDCl3,22.63MHz):12.9,13.9,19.5,21.6,29.0,29.0,33.3,34.5,40.0,118.5,128.7,129.8,129.8,131.1,135.5,137.6,138.0,139.3,153.2,168.6(CO)(Ref. 0004) |
MASS SPECTRA | : | Fragment(m/e):M +300,285,255,105,91,77,55,41(Ref. 0018) |
OTHER SPECTRA | : | Fluorescence (in Ethanol 25![]() X-ray analysis(Ref. 0018/0022) |
CHROMATOGRAM DATA |
SOURCE |
CHEMICAL SYNTHESIS |
METABOLISM |
GENETIC INFORMATION |
NOTE |
REFERENCES |
AUTHOR | : | Michael B. Sporn, Anita B. Roberts, DeWitt S. Goodman,The Retinoids Biology,Chemistry, and Medicine Second Edition, pp229-256, Raven Press, New York |
TITLE | : | |
JOURNAL | : | |
VOL | : | PAGE : - () |
AUTHOR | : | Schwieter, U., Englert, G., Rigassi, N., and Vetter, W. |
TITLE | : | Physical organic methods in carotenoid research PubMed ID:5377333 |
JOURNAL | : | Pure Appl Chem. |
VOL | : | 20 PAGE : 365-420 (1969) |
AUTHOR | : | Englert, G. |
TITLE | : | A 13C-NMR. Study of cis-trans isomeric vitamins A, carotenoids and related compounds PubMed ID:1194053 |
JOURNAL | : | Helv Chim Acta. |
VOL | : | 58 PAGE : 2367-2390 (1975) |
AUTHOR | : | Tsukita kiyoshi, Yoshizawa Tohru, Matsumoto Hiroyuki(1975) Vitamin to Hokouso (eds Nihon Seikagakukai) Chapter.14 Vitamin A pp.549 Tokyo Kagaku Dojin |
TITLE | : | |
JOURNAL | : | |
VOL | : | PAGE : - () |
AUTHOR | : | Lakshmanan, M. R., Vaidyanathan, C. S., and Cama, H. R. |
TITLE | : | Oxidation of vitamin A1 aldehyde and vitamin A2 aldehyde to the corresponding acids by aldehyde oxidase from different species PubMed ID:4953590 |
JOURNAL | : | Biochem J. |
VOL | : | 90 PAGE : 569-573 (1964) |
AUTHOR | : | R.Marbet, Ger. pat. 1971, 2,061,507 (to Hoffmann-La Roche) |
TITLE | : | |
JOURNAL | : | |
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AUTHOR | : | R.Marbet, U.S. pat. 1973, 3,746,730 (to Hoffmann-La Roche) |
TITLE | : | |
JOURNAL | : | |
VOL | : | PAGE : - () |
AUTHOR | : | Seikagaku Hand Book (eds. Nihon Seikagakukai) pp.1274-1277. Tokyo Kagaku Dojin |
TITLE | : | |
JOURNAL | : | |
VOL | : | PAGE : - () |
AUTHOR | : | Michael B. Sporn, Anita B. Roberts, DeWitt S. Goodman (1994) The Retinoids Biology,Chemistry, and Medicine Second Edition pp443-520 Raven Press New York |
TITLE | : | |
JOURNAL | : | |
VOL | : | PAGE : - () |
AUTHOR | : | Michael B. Sporn, Anita B. Roberts, DeWitt S. Goodman (1994) The Retinoids Biology,Chemistry, and Medicine Second Edition pp597-630 Raven Press New York |
TITLE | : | |
JOURNAL | : | |
VOL | : | PAGE : - () |