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Vitamin D


DATA No : VVD0048 INFORMANT : Sachiko Yamada

NAME : (5Z,7E)-(1S,3R)-24-nor-9,10-seco-5,7,10(19)-cholestatriene-1,3,25-triol

COMMON NAME: 1a,25-dihydroxy-24-norvitamin D3 / 1a,25-dihydroxy-24-norcholecalciferol
SYMBOL: 1a,25-(OH)2-24-nor-D3
FORMULA: C26H42O3 MOL.WT (average) : 402.610


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BIOLOGICAL ACTIVITY
HL-60 human promyelocytes differentiation: ED50 in nitro blue tetrazolium reduction, phagocytic activity and nonspecific acid esterase activity are 1.5 times 10-7 M, 1.2 times 10-7 M and 1.6 times 10-7 M, respectively, when 1,25-(OH)2D3 shows the respective ED50 values of 1.0 times 10-8 M, 1.0 times 10-8 M and 1.1 times 10-8 M, respectively. (Ref. 0228)
Biological activity (% of 1,25-(OH)2D3effect) : Intestinal calcium absorption in chick, 2.0% ; Bone calcium mobilization in chick, 2.0% ; Competitive binding to the vitamin D receptor in chick intetine, 1.0% ; Inhibition of clonal growth of human leukemia cells (HL-60), ED50 was not reached. (Ref. 0238)
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REFERENCES
[0228]
AUTHOR:Ostrem, V. K., Lau, W. F., Lee, S. H., Perlman, K., Prahl, J., Schnoes, H. K., and DeLuca, H. F.
TITLE:Induction of monocytic differentiation of HL-60 cells by 1,25-dihydroxyvitamin D analogs PubMed ID:3477545
JOURNAL:J Biol Chem.
VOL:262 PAGE : 14164-14171 (1987)
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[0238]
AUTHOR:Zhou, J. Y., Norman, A. W., Akashi, M., Chen, D. L., Uskokovic, M. R., Aurrecoechea, J. M., Dauben, W. G., Okamura, W. H., and Koeffler, H. P.
TITLE:Development of a novel 1,25(OH)2-vitamin D3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism PubMed ID:1648977
JOURNAL:Blood.
VOL:78 PAGE : 75-82 (1991)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.