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Eicosanoid


DATA No : XPR1724 INFORMANT : Takehiko Yokomizo

NAME : 9a,11a-epidioxy-15S-hydroxy-prost-13E-en-1-oic acid

COMMON NAME: Prostaglandin H1
SYMBOL:
FORMULA: C20H34O5 MOL.WT (average) : 354.481


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BIOLOGICAL ACTIVITY
PGH1 is known as suicide substrate and inhibits platelet thromboxane synthase with a Ki of 28 mM.(Ref. 2029)
PHYSICAL AND CHEMICAL PROPERTIES
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OPTICAL ROTATION:

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SPECTRAL DATA
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IR SPECTRA:

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OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
PGH1 is a cylooxygenase metabolige of DGLA.
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[2029]
AUTHOR:Jones,D.A.,Fitzpatrick,F.A.
TITLE:..Suicide.. inactivation of thromboxane A2 synthase. Characteristics of mechanism-based inactivation with isolated enzyme and intact platelets. PubMed ID:2243085
JOURNAL:J.Biol.Chem.
VOL:265 PAGE : 20166 -20171 (1990)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.