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Eicosanoid


DATA No : XPR1738 INFORMANT : Takehiko Yokomizo

NAME : 9-oxo-11a,15S-dihydroxy-15-methyl-prost-13E-en-1-oic acid

COMMON NAME: 15(S)-15-methyl Prostaglandin E1
SYMBOL:
FORMULA: C21H36O5 MOL.WT (average) : 368.508


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BIOLOGICAL ACTIVITY
15(S)-15-methyl Prostaglandin E1 shows weak constriction effect on human respiratory tract smooth muscle.(Ref. 2045)15(S)-15-methyl Prostaglandin E1 at 300 ng/kg administered systemically (subcutaneously), selectively suppresses PMN-dependent edema formation.(Ref. 2078) In hamsters, 15(S)-15-methyl Prostaglandin E1 of 150 micrograms reduced the number of PMNLs adherent to blood vessels and infiltrating the ICT (infiltrated connective tissue) and other inflammation.(Ref. 2091)
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REFERENCES
[2045]
AUTHOR:Karim, S. M., Adaikan, P. G., and Kottegoda, S. R.
TITLE:Prostaglandins and human respiratory tract smooth muscle: structure activity relationship PubMed ID:7369062
JOURNAL:Adv Prostaglandin Thromboxane Res.
VOL:7 PAGE : 969-980 (1980)
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[2078]
AUTHOR:Rampart, M., and Williams, T. J.
TITLE:Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration PubMed ID:3524253
JOURNAL:Am J Pathol.
VOL:124 PAGE : 66-73 (1986)
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[2091]
AUTHOR:Caillon, P., and Saffar, J. L.
TITLE:Improvement of gingival and alveolar bone status in periodontitis-affected hamsters treated with 15-methyl prostaglandin E1 PubMed ID:8158502
JOURNAL:J Periodontal Res.
VOL:29 PAGE : 138-145 (1994)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.