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Eicosanoid


DATA No : XPR1766 INFORMANT : Takehiko Yokomizo

NAME : 11-oxo-prosta-5Z,9,12E,14Z-tetraen-1-oic acid

COMMON NAME: 15-deoxy-D12.14-Prostaglandin J2
SYMBOL:
FORMULA: C20H28O3 MOL.WT (average) : 316.435


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BIOLOGICAL ACTIVITY
15-deoxy-D12.14-Prostaglandin J2 induces lipogenesis and adipocyte differentiation in cultured cell line.(Ref. 2035) 15-deoxy-D12.14-Prostaglandin J2 shows powerful proapoptotic effects by inhibiting I kappa B alpha degradation.(Ref. 2075)
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REFERENCES
[2035]
AUTHOR:Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., and Lehmann, J. M.
TITLE:A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation PubMed ID:8521498
JOURNAL:Cell.
VOL:83 PAGE : 813-819 (1995)
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[2075]
AUTHOR:Ward, C., Dransfield, I., Murray, J., Farrow, S. N., Haslett, C., and Rossi, A. G.
TITLE:Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism PubMed ID:12055237
JOURNAL:J Immunol.
VOL:168 PAGE : 6232-6243 (2002)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.