Back to HOME

Eicosanoid


DATA No : XPR1788 INFORMANT : Takehiko Yokomizo

NAME : 9a,11a,15S-trihydroxy-(8b)-prosta-5Z,13E-dien-1-oic acid

COMMON NAME: 8-iso Prostaglandin F2a
SYMBOL:
FORMULA: C20H34O5 MOL.WT (average) : 354.481


Download ChemDraw structure data
BIOLOGICAL ACTIVITY
8-iso PGF2a is reported to inhibit platelet aggregation induced by U-46619 (1 mM) and I-BOP (0.3 mM) with IC50 of 1.6 mM and 1.8 mM, respectively.(Ref. 2094)
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
In normal human urine, 8-iso PGF2a level are about 180-200 pg/mg of creatinine.(Ref. 2095)
CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[2094]
AUTHOR:Morrow, J. D., Minton, T. A., and Roberts, L. J., 2nd
TITLE:The F2-isoprostane, 8-epi-prostaglandin F2 alpha, a potent agonist of the vascular thromboxane/endoperoxide receptor, is a platelet thromboxane/endoperoxide receptor antagonist PubMed ID:1438879
JOURNAL:Prostaglandins.
VOL:44 PAGE : 155-163 (1992)
[TOP]

[2095]
AUTHOR:Morrow, J. D., Harris, T. M., and Roberts, L. J., 2nd
TITLE:Noncyclooxygenase oxidative formation of a series of novel prostaglandins: analytical ramifications for measurement of eicosanoids PubMed ID:2321745
JOURNAL:Anal Biochem.
VOL:184 PAGE : 1-10 (1990)
[TOP]

Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.