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Eicosanoid


DATA No : XPR2002 INFORMANT : Shouzo Yamamoto

NAME : 7-[3-(3(S)-Hydroxy-1(E),5(Z)-octadienyl)-1(S),5(S),4,6-dioxabicyclo[3.1.1]hept-2-yl ]-5(Z)-heptenoic acid

COMMON NAME: THROMBOXANE A3
SYMBOL: TXA3
FORMULA: C20H30O5 MOL.WT (average) : 350.449


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BIOLOGICAL ACTIVITY
Thromboxane A3 did not cause platelet aggregation unlike thromboxane A2, and inhibited platelet aggregation by other agonists (Ref. 0090).
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CHEMICAL SYNTHESIS

METABOLISM
Prostaglandin H3 is produced from 5,8,11,14,17-eicosapentaenoic acid, which is one-eighth as efficient a substrate as arachidonic acid, by the catalysis of fatty acid cyclooxygenase, and then transformed to unstable thromboxane A3 (Ref. 0090), which is converted non-enzymatically to stable thromboxane B3.
GENETIC INFORMATION

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REFERENCES
[0090]
AUTHOR:Needleman, P., Raz, A., Minkes, M. S., Ferrendelli, J. A., and Sprecher, H.
TITLE:Triene prostaglandins: prostacyclin and thromboxane biosynthesis and unique biological properties PubMed ID:218223
JOURNAL:Proc Natl Acad Sci U S A.
VOL:76 PAGE : 944-948 (1979)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.