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Eicosanoid


DATA No : XPR2111 INFORMANT : Shouzo Yamamoto

NAME : 5-[Tetrahydro-4(S),6-dihydroxy-2(R)-(3(S)-hydroxy-1(E)-octenyl)-2H-pyran-3(S)-yl]-3(Z)-pentenoic acid

COMMON NAME: 2,3-DINORTHROMBOXANE B2
SYMBOL: 2,3-DINOR-TXB2
FORMULA: C18H30O6 MOL.WT (average) : 342.427


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BIOLOGICAL ACTIVITY

PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:ETHYL ACETATE, DIETHYL ETHER, DICHLOROMETHANE (Ref. 1057)
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:METHYL ESTER ; 1H-NMR(CDCl3) : d 5.77-5.0(m, 6H), 4.50-3.96(m, 5H), 3.71(s, 3H, OCH3), 3.20-3.00(m, 2H) (Ref. 1057)

MASS SPECTRA:METHYL ESTER TRIS-TMS ETHER ; m/e 557, 482, 467, 411, 338, 301, 295, 267, 228, 225, 217 (Ref. 1056)

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE
When thromboxane B2 is infused, 2,3-dinor-thromboxane B2 is found in urine of monkey (Ref. 0031) and man (Ref. 0048) as a major metabolite.
CHEMICAL SYNTHESIS

METABOLISM
2,3-Dinor-thromboxane B2 is a b-oxidation product of thromboxane B2.
GENETIC INFORMATION

NOTE

REFERENCES
[0031]
AUTHOR:Kindahl,H.
TITLE:Metabolism of thromboxane B2 in the cynomolgus monkey. PubMed ID:404670
JOURNAL:Prostaglandins
VOL:13 PAGE : 619 -629 (1997)
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[0048]
AUTHOR:Roberts, L. J., 2nd, Sweetman, B. J., Payne, N. A., and Oates, J. A.
TITLE:Metabolism of thromboxane B2 in man. Identification of the major urinary metabolite PubMed ID:914816
JOURNAL:J Biol Chem.
VOL:252 PAGE : 7415-7417 (1977)
[TOP]

[1056]
AUTHOR:Kindahl,H.
TITLE:Metabolism of Thromboxane B2 in the Cynomolgus Monkey. PubMed ID:404670
JOURNAL:Prostaglandins
VOL:13 PAGE : 619 -629 (1977)
[TOP]

[1057]
AUTHOR:Nelson, N. A., Jackson, R. W., and Sebek, O. K.
TITLE:Synthesis of thromboxane B2 metabolites PubMed ID:704927
JOURNAL:Prostaglandins.
VOL:16 PAGE : 85-92 (1978)
[TOP]

Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.