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Eicosanoid


DATA No : XPR3114 INFORMANT : Takehiko Yokomizo

NAME : N-(2-hydroxyethyl)-5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenamide

COMMON NAME: Leukotriene B4 Ethanolamide
SYMBOL:
FORMULA: C22H37NO4 MOL.WT (average) : 379.534


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BIOLOGICAL ACTIVITY
LTB4-EA is reported as a potent antagonist about 3 fold higher affinity for the human LTB4 receptor that LTB4. And LTB4-EA antagonizes the LTB4-induced contractions of guinea pig lung parenchyma with 10 nM as an EC50.(Ref. 2123)
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REFERENCES
[2123]
AUTHOR:McHugh, D., McMaster, S., Ross, R.
TITLE:Pharmacological characterisation of LTB4 ethanolamide: Interaction with leukotriene and Vanilloid receptors.
JOURNAL:13th Annual ICRS Cannabinoid SYmposium
VOL: PAGE : 121 - (2003)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.