Eicosanoid

DATA No : XPR3114 INFORMANT : Takehiko Yokomizo

NAME : N-(2-hydroxyethyl)-5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenamide

COMMON NAME	:	Leukotriene B4 Ethanolamide
SYMBOL	:
FORMULA	:	C₂₂H₃₇NO₄ MOL.WT (average) : 379.534

Download ChemDraw structure data

BIOLOGICAL ACTIVITY

LTB4-EA is reported as a potent antagonist about 3 fold higher affinity for the human LTB4 receptor that LTB4. And LTB4-EA antagonizes the LTB4-induced contractions of guinea pig lung parenchyma with 10 nM as an EC50.(Ref. 2123)

PHYSICAL AND CHEMICAL PROPERTIES

MELTING POINT	:

BOILING POINT	:

REFRACTIVE INDEX	:

OPTICAL ROTATION	:

DENSITY	:

SOLUBILITY	:

SPECTRAL DATA

UV SPECTRA	:

IR SPECTRA	:

NMR SPECTRA	:

MASS SPECTRA	:

OTHER SPECTRA	:

CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS

METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES

[2123]

AUTHOR	:	McHugh, D., McMaster, S., Ross, R.
TITLE	:	Pharmacological characterisation of LTB4 ethanolamide: Interaction with leukotriene and Vanilloid receptors.
JOURNAL	:	13th Annual ICRS Cannabinoid SYmposium
VOL	:	PAGE : 121 - (2003)

[TOP]