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Eicosanoid


DATA No : XPR3116 INFORMANT : Takehiko Yokomizo

NAME : 5S,12S-dihydroxy-6E,8E,10E,14Z-eicsatetraenoic acid

COMMON NAME: 6-trans-12-epi Leukotriene B4
SYMBOL:
FORMULA: C20H32O4 MOL.WT (average) : 336.466


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BIOLOGICAL ACTIVITY
6-trans-12-epi LTB4 is reported as a weak chemotactic factors for PMNL with 20 times less potency thant LTB4 .(Ref. 2127)
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REFERENCES
[2127]
AUTHOR:Lee, T. H., Menica-Huerta, J. M., Shih, C., Corey, E. J., Lewis, R. A., and Austen, K. F.
TITLE:Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product PubMed ID:6321468
JOURNAL:J Biol Chem.
VOL:259 PAGE : 2383-2389 (1984)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.