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Eicosanoid


DATA No : XPR3302 INFORMANT : Takehiko Yokomizo

NAME : 5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E14Z-eicosatetraenoic acid

COMMON NAME: 11-trans Leukotriene D4
SYMBOL:
FORMULA: C25H40N2O6 MOL.WT (average) : 464.595


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BIOLOGICAL ACTIVITY
The potency for contraction of guinea pig ileum, trachea, and parenchyma of 11-trans LTD4 is 10-25% compared to LTD4.(Ref. 2139/2140)
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REFERENCES
[2139]
AUTHOR:Baker, S. R., Boot, J. R., Jamieson, W. B., Osborne, D. J., and Sweatman, W. J.
TITLE:The comparative in vitro pharmacology of leukotriene D4 and its isomers PubMed ID:6895848
JOURNAL:Biochem Biophys Res Commun.
VOL:103 PAGE : 1258-1264 (1981)
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[2140]
AUTHOR:Tsai, B. S., Bernstein, P., Macia, R. A., Conaty, J., and Krell, R. D.
TITLE:Comparative potency and pharmacology of isomers of leukotriene D4 on guinea-pig trachea: requirement for a 5(S)6(R) configuration PubMed ID:6896758
JOURNAL:Prostaglandins.
VOL:23 PAGE : 489-506 (1982)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.