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Eicosanoid


DATA No : XPR7021 INFORMANT : Keizo Waku

NAME : N-methyl arachidonoyl amide

COMMON NAME:
SYMBOL:
FORMULA: C22H37NO MOL.WT (average) : 331.535


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BIOLOGICAL ACTIVITY
Binding of this compound to the brain cannabinoid receptor (CB1),Ki(nM)= 60.0pm7.4 (Ref. 7001)
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:colorless oil (Ref. 7001)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:1H NMR (CDCl3) d5.80 (br s, lH), 5.30-5.40 (m, 8H), 2.78-2.85 (m, 9H), 2.03-2.19 (m, 6H), 1.66-1.76 (m, 2H), 1.25-1.34 (m, 6H), 0.88 (t, J=9Hz, 3H) (Ref. 7001)

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS
This compound was synthesized from arachidonoylchloride and methylamine.Yield is 67 %.(Ref. 7001)
METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[7001]
AUTHOR:Sheskin, T., Hanus, L., Slager, J., Vogel, Z., and Mechoulam, R.
TITLE:Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor PubMed ID:9057852
JOURNAL:J Med Chem.
VOL:40 PAGE : 659-667 (1997)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.