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Eicosanoid


DATA No : XPR7027 INFORMANT : Keizo Waku

NAME : N-amyl arachidohoyl amide

COMMON NAME:
SYMBOL:
FORMULA: C25H43NO MOL.WT (average) : 373.615


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BIOLOGICAL ACTIVITY
Binding of this compound to the brain cannabinoid receptor (CBl),Ki(nM)>l000 (Ref. 7001)
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:colorless oil (Ref. 7001)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:1H NMR (CDCl3) d5.70 (br s lH), 5.23-5.33 (m, 8H), 3.15 (q, J=3Hz, 2H), 2.71-2.77(m, 6H), 1.97-2.16 (m, 6H), 1.58-1.68 (m, 2H), 1.18-1.42 (m, l2H), 0.79-0.85 (m, 6H). (Ref. 7001)

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS
This compound was synthesized from arachidonoylchloride and amylamine.Yield 70 % (Ref. 7001)
METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[7001]
AUTHOR:Sheskin, T., Hanus, L., Slager, J., Vogel, Z., and Mechoulam, R.
TITLE:Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor PubMed ID:9057852
JOURNAL:J Med Chem.
VOL:40 PAGE : 659-667 (1997)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.