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Eicosanoid


DATA No : XPR7037 INFORMANT : Keizo Waku

NAME : N,N-dimethyl arachidonoyl amide

COMMON NAME:
SYMBOL:
FORMULA: C22H37NO MOL.WT (average) : 331.535


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BIOLOGICAL ACTIVITY
Binding to the rat brain cannabinoid receptor (CBl), Ki(nM)>1000 (Ref. 7001)
PHYSICAL AND CHEMICAL PROPERTIES
MELTING POINT:colorless oil (Ref. 7001)

BOILING POINT:

REFRACTIVE INDEX:

OPTICAL ROTATION:

DENSITY:

SOLUBILITY:
SPECTRAL DATA
UV SPECTRA:

IR SPECTRA:

NMR SPECTRA:1H NMR (CDCl3) d5.24-5.44 (m, 8H), 2.99 (s, 3H), 2.94 (s, 3H), 2.76-2.86 (m, 6H), 2.31 (t, J=7Hz, 2H), 2.00-2.18 (m, 4H), 1.66-1.78 (m, 2H), 1.20-1.38 (m, 6H), 0.89 (t, J=7.lHz, 3H)(Ref. 7001)

MASS SPECTRA:

OTHER SPECTRA:
CHROMATOGRAM DATA

SOURCE

CHEMICAL SYNTHESIS
This compound was synthesized from arachidonoyl chloride and dimethylamine. Yield 59 %. (Ref. 7001)
METABOLISM

GENETIC INFORMATION

NOTE

REFERENCES
[7001]
AUTHOR:Sheskin, T., Hanus, L., Slager, J., Vogel, Z., and Mechoulam, R.
TITLE:Structural requirements for binding of anandamide-type compounds to the brain cannabinoid receptor PubMed ID:9057852
JOURNAL:J Med Chem.
VOL:40 PAGE : 659-667 (1997)
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Last updated June 19, 2007. Copyright © 1989-2007 Japanese Conference on the Biochemistry of Lipids (JCBL). All rights reserved.