Category:LBS

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Sphingolipid

Contents

Class Overview

Sphingosine & Ceramide

Sphingosine is synthesized from decarboxylating condensation of palmitoyl CoA with serine. It is a 18-carbon amino alcohol (16 carbons from palmitic acid and 2 from serine) with one unsaturated bond (2-amino-4-octadecene-1,3-diol). Sphingosine is further acylated to form ceramide, an important component of cell membranes.
The Sphingolipid category (LBS) in this database includes glycosphingolipid, phosphosphingolipid, and ceramide.

スフィンゴシンはパルミトイルCoAがアミノ酸セリンと脱炭酸縮合して生成します。炭素を18個含むアミノアルコール(16個がパルミチン酸、2個がセリン由来)で不飽和結合を1つ含んでいます (2-amino-4-octadecene-1,3-diol)。 スフィンゴシンがアシル化したものが、細胞膜の重要な成分であるセラミドです。
このデータベースにおけるスフィンゴ脂質カテゴリー (LBS) には、スフィンゴ糖脂質 (glycosphingolipid)、スフィンゴリン脂質 (phosphosphingolipid) 、セラミド (ceramide) が含まれています。

Common Abbreviations

Page/ID Design for Sphingolipid

L B S s1 s2 s3 n1 n2 y c c1 c2

  • s1 ∼ s3 ... Structure code (3 digits)
Explained below
  • n1, n2 ... the number of sugars (2 digits)
  • y ... the number of sialic acids ( 1 digit)
  • c ... ceramide identification (1 digit)
  • c1, c2 ... serial numbers

  • s1 ∼ s3 ... 構造コード (3桁）
下に詳述
  • n1, n2 ... 糖の数 (2桁)
  • y ... シアル酸の数 (1桁)
  • c ... セラミドの同定 (1桁)
  • c1, c2 ... 通し番号

Structure Code

code Galactose
0 no sugar
1 Galactose
(α form) 		Galα1-3 ...
2 Galα1-4 ...
3 Galα1-6 ...
4 Galactose
(β form) 		Galβ1-3 ...
5 Galβ1-4 ...
6 Galβ1-6 ...
code N-Acetylated Sugars
7 N-Acetyl Galactosamine
(β form) 		GalNAcβ1-3 ...
8 GalNAcβ1-4 ...
9 GalNAcβ1-6 ...
A N-Acetyl Glucosamine
(β form) 		GlcNAcβ1-3 ...
B GlcNAcβ1-4 ...
C GlcNAcβ1-6 ...


code Galactose & Glucose
D Aminated Sugars
(Except for Code 7∼C) 		GalNAc, GalN
E GlcNAc, GlcN
F Galactose
(Except Code 1∼6) 		Gal
G Glucose Glc
code Other Sugars
J Inositol (Ins)
K Fucose (Fuc)
L Pentose sugars
(Ara, Xyl)
M Mannose and Rhamnose (= 6-deoxymannose)
(Man, Rha)
N Neuraminic acids
(NeuAc, NeuNH, NeuGc, KDN)
code Modifiers
P Phosphate (HPO4), Sulphate (HSO4),
and Phosphocholine (PC)
Q Aminoethylphosphates
AEPn, MAEPr, EtnP
R O-Alkyl and O-acyl groups
OAc, CH3, 2C=CH
code Abbreviations
Y GlcNAcβ1-3Manβ1-4Glcβ1-1Cer
Z Galβ1-4Glcβ1-1bCer


NOTE

Most common patterns
  • GalNAcβ1-4Galβ1-4-Glcβ1-Cer
Ganglio series ... over 110 molecules
  • GlcNAcβ1-3Galβ1-4-Glcβ1-Cer
Lacto or Neolacto series ... over 170 molecules
  • Neuraminic acid + Galβ1-4-Glcβ1-Cer
??... over 50 molecules
  • GlcNAcβ1-3Manβ1-4Glcβ1-1Cer
Arthro series ... over 50 molecules
Digits

"I" and "O" are not used to avoid confusion with "1" or "0".

Polysaccharide Chain

Table 1. Common Categories
Common Name Sequence LipidBank ID
By GalCer Synthase (EC 2.4.1.62)
Gala Galα1-4Galβ1-Cer LBSF2.
Spirometo Galβ1-4Glcβ1-3Galβ1-Cer LBSFG5
By GlcCer Synthase (EC 2.4.1.80)
Ganglio GalNAcβ1-4Galβ1-4Glcβ1-Cer LBSZ8.
Isoganglio GalNAcβ1-3Galβ1-4Glcβ1-Cer LBSZ7.
Globo Galα1-4Galβ1-4Glcβ1-Cer LBSZ2.
Isoglobo Galα1-3Galβ1-4Glcβ1-Cer LBSZ1.
Lacto Galβ1-3GlcNAcβ1-3Galβ1-4Glcβ1-Cer LBSZD4
NeoLacto Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-Cer LBSZA5
Muco Galβ1-4Galβ1-4Glcβ1-Cer LBSZ5.
With Mannose
Arthro GlcNAcβ1-3Manβ1-4Glcβ1-Cer LBSY
Mollu Manα1-3Manβ1-4Glcβ1-Cer LBSGMM

Classification

By the Number of Sugars 糖の個数

For glycosphingolipid, 2 digits following LBS stand for the number of attached sugars. For phosphosphingolipid, the code of phosphorylation, PP.

スフィンゴ糖脂質は結合している糖の総数をLBSに続く2桁の数字で、スフィンゴリン脂質は数字の代わりにリン酸化修飾を示す記号PPで分類しています。

Sphingolipid Overview

Glycosphingolipid
スフィンゴ糖脂質: LBSnn

Phosphosphingolipid
スフィンゴリン脂質: LBSPP

Table 1. Classification by the Number of Sugars
 LBS...01:
1 sugar
糖の数1
 (40 pages) 		 LBS...02:
2 sugars
糖の数2
 (44 pages) 		 LBS...03:
3 sugars
糖の数3
 (80 pages) 		 LBS...04:
4 sugars
糖の数4
 (90 pages)
 LBS...05:
5 sugars
糖の数5
 (115 pages) 		 LBS...06:
6 sugars
糖の数6
 (109 pages) 		 LBS...07:
7 sugars
糖の数7
 (88 pages) 		 LBS...08:
8 sugars
糖の数8
 (59 pages)
 LBS...09:
9 sugars
糖の数9
 (37 pages) 		 LBS...10:
10 sugars
糖の数10
 (22 pages) 		 LBS...11:
11 sugars
糖の数11
 (14 pages) 		 LBS...12:
12 sugars
糖の数12
 (12 pages)
 LBS...13:
13 sugars
糖の数13
 (0 pages) 		 LBS...14:
14 sugars
糖の数14
 (5 pages) 		 LBS...15:
15 sugars
糖の数15
 (5 pages) 		 LBS...16:
16 sugars
糖の数16
 (2 pages)
 LBS...17:
17 sugars
糖の数17
 (1 pages) 		 LBS...18:
18 sugars
糖の数18
 (2 pages) 		 LBS...19:
19 sugars
糖の数19
 (0 pages) 		 LBS...20:
20 sugars
糖の数20
 (4 pages)
 LBS...21:
21 sugars
糖の数21
 (0 pages) 		 LBS...22:
22 sugars
糖の数22
 (2 pages) 		 LBS...00:
0 sugar
糖の数0
 (0 pages) 		 LBS...PP:
Sphingophospholipid
スフィンゴリン脂質
 (0 pages)

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